Hadi Hashemzade, Alireza Zebarjadi, Nasim Akhshi, Kazem Aghaee
Campus of Agriculture and Natural Resources, Razi University, Kermanshah, Islamic Republic of Iran
Department of Plant Breeding, Lorestan University, Islamic Republic of Iran
Department of agricultural management, college of agriculture, Tehran science and research branch, Islamic Azad university, Tehran, Islamic Republic of Iran
Key words: Plant-derived pharmaceutical, edible vaccine, expression system, plantibody, antibody.
Abstract
Antibodies (Ab) are glycoprotein compounds produced by the vertebrate immune-system. They recognize and bind to their aim antigens with high affinity and specificity, which enable them to be used for numerous applications, such as the diagnosis, prevention, resistance to pathogens of plant, and cure of human and animal illness. The importance of antibodies as an in vitro investigation tool has been incorporate in vivo applications in basic researches of proteins and other compounds. Recently, the production of antibodies in plants because many reasons, including low-cost production, ease to storage large-scale production, safety and etc. is proposed. This technology is referring to the plantibody. Plantibody approach is one of the new events in molecular technology field. Plants as a bio-factory can be also used for biopharmaceutical and drugs production. Pharmaceuticals that derived from plants are poised to become the next major commercial development in plant biotechnology. But, however, there are some concerns in this context. In the present article, we try to summarize the recent advances made in the use of transgenic plants as biological factories for the production of drugs, vaccine, and biopharmaceuticals also discuss the plantibodies as a low-cost, efficient method for the production of biological materials with demonstrated utility to the pharmaceutical industry or medical community. In addition, a referring to applications of antibodies produced in plants and has been compared with other expression system.
Get the original articles in Source: Volume 4, Number 4, April 2014 – JBES
Journal Name: Journal of Biodiversity and Environmental Sciences (JBES)
Published By: International Network for Natural Sciences
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